A Spanish biomedical research networking center has developed a new disposable and miniaturized array of electrochemical sensors for the minimally invasive monitoring of tissue ischemia. They are looking forward to establishing license, research cooperation, or joint venture agreements.

This Spanish research networking center gathers some of the main Spanish research groups in biomedicine, located in more than 100 institutions like universities, hospitals, and technological centers distributed around the country.
Monitoring tissue ischemia is key to avoid irreparable damage or even tissue loss due to blood perfusion impairment. Tissue ischemia control is commonly required on reconstructive surgery units, where microsurgical anastomosis of tissue flap vessels is routinely performed by clinical observation of general symptoms; as well as in trauma units, where compartmental syndrome (i.e. raise of tissue pressure due to severe trauma and consequent loss of blood perfusion) is a main concern. Currently, the control of tissue ischemia is based on the clinical observation of subjective symptomology (e.g. skin color or turgence). Therefore, microcirculatory complications are normally detected after 5-8 days post-surgery, when tissue salvage rate is very low. Thus, reliable methods for earlier detection of tissue ischemia are required.
The present invention describes a new disposable and miniaturized array of electrochemical sensors for the minimally invasive monitoring of tissue ischemia. The device was pre-validated for hypoxia monitoring by means of pH and O2 detection in tissue and blood in rabbit model.
Large-scale prototype tested on stomach pig-model is available. Micro-sized prototype is under development. Multi-sensing integration has been achieved.
The research center is seeking companies of the bio and pharma sectors willing to establish license agreements, research cooperation for clinical proof of concept, or joint venture agreements to callaborate in innovation projects.

The technology is based on the detection of physiological changes that occur under ischemia conditions, which are analyzed by means of potentiometry and bioimpedance. This wireless sensor permits the continuous control of deep tissues, whose blood perfusion may be compromised. 
Ischemia control by means of this technology can be carried out by both physicians and caregiver professionals. Moreover, the small dimensions of the sensor as well as the probe design, permits this sensor to be easily removed from the site of insertion with minimal pain and risk. 
In case of ischemia complications, the device will permit an immediate surgical response before irreversible tissue damage occurs.

Large-scale prototype tested on stomach pig-model is available. Micro-sized prototype is under development. Multi-sensing integration has been achieved.

European patent application (Priority date: July 30, 2020)
Suitable for International extension (PCT application)

Patent ready for licensing-out. Any of the next types of collaborations are sought:
•	Industry from the bio or pharma sectors for further development of the device (clinical proof-of-concept), in order to collaborate in innovation projects
•	Industry from the bio or pharma sectors willing to licensing-in the technology (product)
•	Research organization for further development of the device, in order to collaborate in innovation projects (clinical proof-of-concept)